CONSTRUCTS CONTAINING COMPOSITE EXPRESSION CASSETTES FOR THERAPY OF CANCER Russian patent published in 2013 - IPC C12N15/11 C12N15/31 C12N15/63 A61K48/00 A61P35/00

Abstract RU 2487165 C2

FIELD: medicine.

SUBSTANCE: what is presented is a nucleic acid construct for treating tumours comprising at least two open reading frames that include sequences encoding a cytotoxic or cytostatic gene product, in particular diphtheria toxin functionally related to various tumour-specific promoters: H19-specific promoter, IGF-II P3 or P4 promoter. What is described is a eukaryotic expression vector comprising the above nucleic acid construct, and methods of treating and inhibiting the tumour development in a human subject by administering the nucleic acid construct under the invention.

EFFECT: invention can find further application in therapy of cancer.

33 cl, 12 ex, 40 dwg

Similar patents RU2487165C2

Title	Year	Author	Number
METHODS AND COMPONENTS FOR INDUCTION OF TUMOR- -SPECIFIC CYTOTOXICITY	1998	Khokhberg Abrakham Ajesh Sukhail	RU2214280C2
METHODS OF EX VIVO EXPANSION OF NATURAL KILLER CELLS AND THEIR USE	2019	Shpall, Elizabeth Rezvani, Katy	RU2814083C2
SYSTEM DELIVERY AND REGULATED EXPRESSION OF PARACRINE GENES FOR TREATMENT OF CARDIOVASCULAR AND OTHER DISEASES	2013	Khemmond Kh. Kerk Gao Mej Khua	RU2642605C2
CELL BASED QUALITY CONTROL BIOASSAYS FOR NUTRICEUTICAL AND MEDICINAL PRODUCTS	2013	Khalperin Zhoze A. Chorev Majkl Aktas Khusejn	RU2662358C2
MUTANT STRAIN OF HEPATITIS B VIRUS AND ITS USING	1998	Oon Chong Dzhin Lim Gek K'Ju Zhao Jui Chen Vej Ning	RU2270863C2
MODIFIED DENDRITE CELLS AND THEIR USE IN TREATMENT OF MALIGNANT TUMOURS	2008	Brauler Dzh. Mark Kumar Prasanna Storkus Uolter Dzh. Okada Khidekho	RU2484132C2
MODIFIED MONOCYTES/MACROPHAGES EXPRESSING CHIMERIC ANTIGEN RECEPTORS AND THEIR APPLICATIONS	2016	Gill, Saar Klichinsky, Michael June, Carl H.	RU2766690C2
METHOD AND COMPOSITION FOR DIAGNOSING AND TREATING CANCER	1996	Slejmen Gehri L.	RU2174409C2
MODIFIED DENDRITIC CELLS AND THEIR APPLICATION FOR MALIGNANT TUMOURS TREATMENT	2013	Brauler Dzh. Mark Kumar Prasanna Storkus Uolter Dzh. Okada Khidekho	RU2644210C2
CANCER TREATMENT USING CHIMERIC ANTIGEN-SPECIFIC RECEPTOR BASED ON HUMANISED ANTI-EGFRvIII ANTIBODY	2014	Brogdon Dzhennifer Dzhonson Laura Aleksandra Dzhun Karl Kh. Lev Andreas Maus Marsela Sholler Dzhon Okada Khidekho	RU2708032C2

RU 2 487 165 C2

Authors

Khokberg Avraam

Amit Doron

Dates

2013-07-10—Published

2008-10-23—Filed