FIELD: chemical technology, pharmacy. SUBSTANCE: invention relates to method for preparing carvedilol of the formula (I) 
, its optically active R- or S-enantiomers, mixtures of these enantiomers and their pharmaceutically acceptable addition salts. Method involves interaction of 4-oxyranylmethoxy-9H-carbazole or its R- or S-enantiomers with N-[2-(2-methoxyphenoxy)ethyl]benzylamine in proton organic solvent and prepared benzyl-carvedilol is debenzylated by reaction of catalytic hydrogenation. Method allows increasing economical indices at the yield 80%. EFFECT: improved preparing method, enhanced yield. 4 cl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING PHARMACEUTICAL PRODUCT | 1998 |
|
RU2245875C2 |
| METHOD OF SYNTHESIS OF 4-HYDROXY-9H-CARBAZOLE | 1998 |
|
RU2204551C2 |
| METHOD FOR PREPARING {2-[4-(ALPHA-PHENYL-PARA-CHLOROBENZYL)PIPERAZINE-1-YL]ETHOXY}-ACETIC ACID AND NEW INTERMEDIATE COMPOUNDS | 2000 |
|
RU2248974C2 |
| METHOD FOR PREPARING 5-CHLORO-4-AMINO-SUBSTITUTED DERIVATIVE OF 3(2H)-PYRIDAZINONE | 1998 |
|
RU2211217C2 |
| METHOD OF PREPARING FLUOXETIN | 1997 |
|
RU2173679C2 |
| AMORPHOUS CALCIUM ATORVASTATINE PREPARATION METHOD | 2000 |
|
RU2255932C2 |
| METHOD FOR PREPARING QUETIAPINE AND INTERMEDIATE COMPOUNDS | 2001 |
|
RU2258067C2 |
| METHOD FOR PREPARING 6-METHYL-2-(4-METHYLPHENYL)-IMIDAZOLO[1,2-A]PYRIDINE-3-(N,N-DIMETHYLACETAM IDE), ESTERS, CRYSTALLINE ESTERS, METHOD FOR THEIR PREPARING | 2000 |
|
RU2254334C2 |
| METHOD OF SYNTHESIS OF 3-ETHYL-5-METHYL-2-(2-AMINOETHOXYMETHYL)- -4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDRO-3,5-PYRIDINE DICARBO-XYLATE AND BENZENESULFOACID SALT (AMLODIPINE BEZYLATE) | 1998 |
|
RU2163597C2 |
| DERIVATIVES OF 2,3-BENZODIAZEPINE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT | 2000 |
|
RU2243228C2 |
