FIELD: organic chemistry, chemical technology, medicine, pharmacy.
SUBSTANCE: invention relates to a method for preparing {2-[4-(α-phenyl-p-chlorobenzyl)piperazine-1-yl]ethoxy}acetic acid (cetirizine) of the formula (I): 
(I).
Method involves hydrolysis of compound of the formula (II): 
(II)
wherein R1 and R2 represent independently (C1-C4)-alkyl that can be substituted with phenyl, (C2-C4)-alkenyl or cyclohexyl; or R1 and R2 in common with adjacent nitrogen atom form morpholine group. Hydrolysis is carried if necessary in the presence of interphase catalyst. Cetirizine is used as a component in anti-allergic pharmaceutical compositions. Also, invention describes a method for preparing intermediate compounds of the formula (II).
EFFECT: improved preparing method, valuable medicinal properties of compound.
5 cl, 25 ex
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