FIELD: organic chemistry, chemical technology, pharmacy.
SUBSTANCE: invention relates to a new method for preparing 1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}-2-propanol of the formula (I):
and its pharmaceutical salts of acids addition. Method involves interaction of secondary amine of the formula (V):
with epichlorohydrine and synthesized chlorine-containing compound of the formula (VI):
reacts with 4-hydroxy-9H-carbazole of the formula:
and synthesized benzyl-carvedilol of the formula (VIII):
is debenzylated by the catalytic hydrogenation reaction. If necessary, the synthesized compound is subjected for reaction with inorganic or organic acid for preparing its pharmaceutically acceptable salt of acid addition.
EFFECT: improved preparing method.
8 ex
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|
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RU2265011C2 |
