FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to new derivatives of 2,3-benzodiazepine of the formula (1): 
wherein radicals R1-R4 have values given in the description. Proposed compounds elicit the neuroprotective effect. Also, invention relates to methods for their preparing, pharmaceutical composition based on thereof and methods for treatment of symptoms accompanying with all types of acute and chronic neurodegeneration. Invention provides preparing new biologically active compounds.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
31 cl, 4 tbl, 39 ex
| Title | Year | Author | Number |
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RU2146678C1 |
| DERIVATIVES OF 2,3-BENZODIAZEPINE, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND AGENT ELICITING INHIBITORY ACTIVITY WITH RESPECT TO AMPA-RECEPTORS | 1997 |
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| METHODS OF SYNTHESIS IF DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES AND INTERMEDIATE COMPOUNDS | 1995 |
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| CAMPOTECIN COMPOUNDS, METHODS OF PREPARATION THEREOF, INTERMEDIATES, AND THERAPEUTIC COMPOSITIONS | 1996 |
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| DERIVATIVES OF 8-SUBSTITUTED=9H-1,3-DIOXOL[4,5-H][2,3]- BENZODIAZEPINE AS INHIBITORS OF AMPA/KAINATE RECEPTOR, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT | 1998 |
|
RU2208013C2 |
| PHYSICAL FORM OF (R)-7-ACETYL-5-(4-AMINOPHENYL)-8,9- DIHYDRO-8-METHYL-7H-1,3-DIOXOLO [4,5-h]-[2,3]- BENZODIAZEPINE, METHOD OF PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2142465C1 |
| PHYSICAL FORM OF (R)-7-ACETYL-5-(4-AMINOPHENYL)-8,9-DIHYDRO- -8-METHYL-7H-1,3-DIOXOLO[4,5-H]-[2,3]-BENZODIAZEPINE, METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION | 1995 |
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| SUBSTITUTED PYRIMIDINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, OR N-OXIDES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1992 |
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| METHOD FOR PREPARING DIHYDROINDENAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND USING THEM AS PROTEIN KINASE INHIBITOR | 2009 |
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RU2528408C2 |
| CONDENSED HETEROCYCLIC COMPOUNDS | 2006 |
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