METHOD FOR DIFFERENTIATED EVALUATION OF HEMOSTASIS IN PREMATURE NEONATALS Russian patent published in 2003 - IPC

FIELD: medicine, pediatrics, neonatology. SUBSTANCE: one should detect the values for intensity of spontaneous thrombocytic aggregation (Ar), period for active prothrombinase development reaction (r), thrombin constant characterizing the time for prothrombin conversion into thrombin (k), blood clotting constant characterizing the time of fibrinogen conversion into fibrin (t), time for developing fibrin-thrombocytic structure of clot (T), fibrin-thrombocytic blood constant characterizing structural properties of clot (AM) and total value of reaction and spontaneous lysis of clot (F) and at values of these parameters Ar being below -4 relative units, r - below 3 min, k below 4 min, t below 38 min, T below 45 min, AM above 750 relative units, F below 7% one should evaluate the state of chronometric and structural hypercoagulation at decreased fibrinolytic activity; at Ar below -4 relative units, r below 3 min, k ranged 2.5-4 min, t below 38 min, T below 45 min, AM below 600 relative units, F ranged 7-19% one should evaluate the state of chronometric hypercoagulation, structural hypocoagulation at normal fibrinolytic activity; at Ar below -4 relative units, r below 3 min, k ranged 2.5-4, t below 38 min, T below 45 min, AM above 750 relative units, F above 19% one should evaluate the state of chronometric and structural hypercoagulation at increased fibrinolytic activity; at Ar above -10 relative units, r above 5 min, k equal to 4 min and more, t ranged 38-46 min, T ranged 45-55 min, AM below 600 relative units, F below 7% one should detect the state of chronometric and structural hypocoagulation at decreased fibrinolytic activity; at Ar ranged -4 - -10 relative units, r above 5 min, k ranged 2.5-4 min, t below 38 min, T below 45 min, AM below 600 relative units, F ranged 7-19% one should evaluate the state of chronometric and structural hypocoagulation at normal fibrinolytic activity; at Ar being below -4 relative units, r above 5 min, k ranged 2.5- 4 min, t below 38 min, T below 45 min, AM above 750 relative units, F above 19% one should detect the state of different alterations in chronometric and structural coagulation at increased fibrinolytic activity; at Ar below -4 relative units, r ranged 3-5 min, k ranged 2.5-4 min, t below 38 min, T below 45 min, AM ranged 600-750 relative units, F below 7% one should evaluate the state of chronometric and structural normocoagulation at decreased fibrinolytic activity and at Ar ranged -4 - -10 relative units, r ranged 3-5 min, k ranged 2.5-4 min, t below 38 min, T below 45 min, AM ranged 600-750 relative units, F above 19% it is possible to evaluate the state of chronometric and structural normocoagulation at increased fibrinolytic activity. The method in question enables to increase sensitivity and information value in differentiated evaluation of hemostasis in premature neonatals. EFFECT: higher efficiency of evaluation. 2 ex, 9 dwg, 2 tbl