FIELD: medicine, pharmacy. SUBSTANCE: invention relates to method for enhancement of bioavailability of taxane in oral administration in combination with cyclosporin, to method for treatment of diseases showing sensitivity to taxane and, respectively, oral pharmaceutical medicinal formula. Invention provides the increase of square under pharmacokinetic curve of docetaxel from 8% after independent intake per os to 90% after the combined administration with cyclosporin A due to not only effect on cytochrome P-450 (isoform 3A4) but by inhibition of glycoprotein-P in digestive tract mucosa also. This allows the enhancement of effectiveness of taxane sharply in the proposed medicinal formula combined with cyclosporin and effectiveness of treatment of disease that is sensitive to taxane. EFFECT: enhanced and valuable medicinal properties of method and compositions. 53 cl, 10 tbl, 13 ex
