FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine. Following is proposed: combinations comprising 8-[(1R)-1-(3,5-difluorophenylamino)ethyl]-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (Compound I) or a pharmaceutically acceptable salt thereof and docetaxel for the treatment of castration-resistant prostate cancer, wherein the compound [I] or a pharmaceutically acceptable salt thereof is dosed intermittently; use of said combination for the treatment of the breast cancer with the triple negative phenotype, wherein the compound [I] or a pharmaceutically acceptable salt thereof is dosed intermittently.
Compound [I].
EFFECT: stable additional anti-cancer activity of the combination even at a low dose of the compound [I] and its intermittent administration for the mentioned forms of cancer.
10 cl, 4 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| SYNERGISTIC COMBINATIONS OF AURISTANE | 2015 |
|
RU2717570C2 |
| MUTANT SELECTIVITY AND COMBINATIONS OF A PHOSPHOINOSITIDE-3-KINASE INHIBITOR COMPOUND AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER | 2013 |
|
RU2665949C2 |
| COMBINATIONS (COMPOSITIONS), INCLUDING DMXAA FOR CANCER TREATMENT | 2006 |
|
RU2404764C2 |
| CHEMICAL COMPOUNDS | 2014 |
|
RU2644769C2 |
| COMBINATIONS OF INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE AND CHEMIOTHERAPEUTIC AGENTS AND METHODS OF APPLICATION | 2008 |
|
RU2523890C2 |
| TREATMENT OF CANCER BY COMBINATION OF PLINABULIN AND TAXANE | 2013 |
|
RU2662298C2 |
| METHOD OF CANCER TREATMENT | 2005 |
|
RU2361589C2 |
| USE OF QUINOLINE DERIVATIVES FOR TREATING OESOPHAGEAL CANCER, AS WELL AS A METHOD OF TREATING, A PHARMACEUTICAL COMPOSITION AND A KIT USING IT | 2017 |
|
RU2734260C2 |
| COMBINATION CONTAINING N-METHOXY-3-METHYLPYRAZINE-2-YL)-2-(4-[1,3,4-OXADIAZOL-2-YL]PHENYL)PYRIDINE-3-SULFONAMIDE AND ANTIMITOTIC SUBSTANCE FOR MALIGNANT GROWTH | 2005 |
|
RU2428188C2 |
| ON01910NA ENHANCING ACTIVITY OF CHEMOTHERAPEUTIC AGENT IN DRUG-RESISTANT TUMOURS | 2008 |
|
RU2476239C2 |
