HUMANIZED ANTIBODIES THAT RECOGNIZE VEROTOXIN II AND CELL LINE PRODUCING THEREOF Russian patent published in 2003 - IPC

FIELD: medicine, cellular biology. SUBSTANCE: invention relates to the humanized antibodies that recognize verotoxin II and cell line producing thereof. Invention provides creature of the humanized antibody representing the humanized form of murine antibody VTm.1 that is characterized by variable region of light chain and variable region of heavy chain and that binds and nutrilizes VT2 or its variant specifically. Invention relates also to pharmaceutical compositions and methods for treatment using indicated antibodies. The advantage of invention involves preparing antibodies without immunogenicity for humans but eliciting properties of murine antibody that can be prepared by methods useful for therapeutical application. EFFECT: valuable medicinal and immunological properties of antibodies. 25 cl, 6 tbl, 7 dwg, 12 ex