THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR DEMENTIA Russian patent published in 2018 - IPC A61K39/395 A61P25/28 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and concerns a monoclonal antibody that specifically binds to a tau protein, phosphorylated in the serine residue corresponding to the serine residue at position 413 of the tau protein, having an amino acid sequence SEQ ID NO: 1, comprising a heavy chain variable region with three complementarity determining regions (CDRs) and a light chain variable region with three complementarity determining regions (CDRs). Group of inventions also relates to a method of treating taupathy, comprising administering to a patient, in need thereof, said monoclonal antibody.

EFFECT: group of inventions provides a reduction in the degree of manifestation of pathology in the brain and improvement of impaired memory.

9 cl, 10 ex, 29 dwg, 6 tbl