HUMANIZED ANTIBODIES THAT RECOGNIZE ALPHA-SYNUCLEINE Russian patent published in 2021 - IPC C07K16/18 C12N15/13 A61K39/395 A61P25/16 C07K16/28

Abstract RU 2743738 C2

FIELD: biochemistry.

SUBSTANCE: in particular, the invention relates to an antibody that specifically binds to human alpha-synuclein. Nucleic acid encoding the said antibody; a host cell for producing the said antibody; a pharmaceutical composition containing the said antibody are also disclosed. Disclosed are methods of treatment using the indicated antibodies; Lewy body detection and reducing Lewy body formation, using the specified antibodies; inhibiting the formation of synuclein aggregates with the help of the specified antibody; a method of producing the specified antibody and the specified cell.

EFFECT: invention makes it possible to effectively treat diseases associated with human alpha-synuclein.

38 cl, 4 ex, 4 tbl, 6 dwg

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RU 2 743 738 C2

Authors

Saldanha Jose

Nijjar Tarlochan S.

Dates

2021-02-25—Published

2012-10-26—Filed