METHOD FOR PREPARING 4-(2-AMINOETHYL)PHENOL Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing 4-(2-aminoethyl)phenol (tyramine) that relates to therapeutically important derivatives of 2-phenylethylamine that elevate blood pressure and they obtained name "pressor" preparations. In the last time tyramine obtained new applications for medicinal aims - in production of textile material of medicinal designation and as intermediate compound in synthesis of enzyme Xa also. Method involves heating 4-(2-hydroxyethyl)-2,6-di-tert. -butylphenol at 120-130 C with hydrobromic acid with simultaneous removal of water and tert.-butyl bromide from reaction mass to yield 4-(2-bromoethyl)phenol that is kept in methanol solution with ammonia at temperature 10-15 C to yield tyramine hydrobromide that is treated with alkaline solution. Method provides preparing tyramine from available parent compound for two chemical stages, to obtain tyramine hydrobromide from phenol without isolation and purification of intermediate 4-(2-bromoethyl)phenol. EFFECT: improved preparing method, high yield.