FIELD: chemistry.
SUBSTANCE: method is described that involves the reaction of 3-mercapto-1,2,4-triazino[5,6-b]indole with 2-morpholinoethylbromide hydrobromide in the presence of an excess of alkali to produce the 3-(2-morpholinoethylthio)-1,2,4-triazino[5,6-b]indole base, wherein 58 ml of concentrated hydrochloric acid, 12 ml of water and 13 ml of propanol-2 are charged into a vessel equipped with a stirrer, thermometer and reflux refrigerator, 10.69 g of the 3-(2-morpholinoethylthio)-1,2,4-triazino[5,6-b]indole base is added with stirring; with stirring, it is boiled for 30 minutes, filtered in the hot state, with stirring, cooled to 25°C, left in the refrigerator for 20 hours; the precipitate is filtered off, washed with propanol-2 and acetone, dried in air to the constant weight; a yellow crystalline product is obtained.
EFFECT: excluding operations with gaseous hydrogen chloride, reducing the consumption of organic solvents, increasing the purity of the product.
1 ex, 8 dwg
| Title |
Year |
Author |
Number |
| AGENT FOR TREATMENT OF PATIENTS WITH ACUTE AND SUDDEN SENSONEURAL DIMINISHED HEARING AND DEAFNESS |
1997 |
- Pastushenkov L.V.
- Tomchin A.B.
- Lin'Kov V.I.
- Pastushenkov A.L.
|
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| 3-ETHYLTHIO-5-(2-MORPHOLINO)-ETHYL-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIINFLAMMATORY, ANTIHYPOXIC ACTIVITY AND CAPABILITY TO INCREASE RESISTANCE TO REPEATED CRANIOCEREBRAL TRAUMA |
1982 |
- Tomchin A.B.
- Ponomareva M.M.
- Pastushenkov A.L.
- Gatchina T.A.
- Balljuzek F.V.
- Seleznev L.G.
- Stepnykh Ju.P.
- Pastushenkov V.L.
- Nalimov Ju.D.
- Pastushenkov L.V.
|
SU1059866A1 |
| METHOD FOR PREVENTING AND TREATING MOTION SICKNESS AND AGENT FOR PREVENTING AND TREATING MOTION SICKNESS (VARIANTS) |
2019 |
- Pastushenkov Vladimir Leonidovich
- Gerasimov Viktor Ivanovich
- Glaznikov Lev Aleksandrovich
- Pastushenkov Aleksandr Leonidovich
|
RU2753952C2 |
| DIHYDROCHLORIDE OF MONOHYDRATE OF 8-BROMO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO/5,6-B/INDOLE HAVING PROTECTING ACTIVITY AGAINST STRESS AND INCREASING PHYSICAL RESISTANCE |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Smirnov A.V.
- Katkova E.B.
- Lozinskij M.O.
- Bobkov Ju.G.
|
SU1220301A1 |
| 8-METHYL-3-(2-MORPHOLINOETHYLTHIO)-5H-1,2,4-TRIAZINO[5,6-B]INDOLE DIHIDROCHLORIDE HYDRATE SHOWING CAPABILITY TO ACCELERATE RECOVERY OF CEREBRUM FUNCTION IN THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
RU1764298C |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHOXY-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Krjukova L.M.
- Zelenin K.N.
|
SU1552605A1 |
| 8-METHOXY-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]- INDOLE MALATE SHOWING ANTIHYPOXIC ACTIVITY |
1988 |
- Tomchin A.B.
- Marysheva V.V.
- Katkov V.F.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1547280A1 |
| 3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE HYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING |
1989 |
- Tomchin A.B.
- Spivakova R.P.
- Smirnov A.V.
|
SU1623156A1 |
| DIHYDROCHLORIDE OF 3-(2-DIMETHYLAMINO)ETHYLAMINO-1,2,4-TRIAZINO(5,6-B)INDOLE IMPROVING RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Makeev B.L.
|
SU1235181A1 |
| PLATELET DESAGREGANT |
0 |
- Tulupov Aleksandr Nikolaevich
- Pastushenkov Leonid Vasilevich
- Belskikh Andrej Nikolaevich
- Akmuradov Arslan Churievich
|
SU1672373A1 |
