FIELD: medicine, peptides, pharmacy. SUBSTANCE: invention relates to a medicinal composition containing at least one peptide with immunomodulating effect or protein (fragment) in combination with an accessory agent. Peptide is isolated from pathogen or antigen raised against tumor. Accessory agent shows property to enhance degree of peptide binding with cells of body, patient to be treated or to enhance peptide absorption by cells and to intensify immunomodulating effect of peptide also. Preferable accessory agents are basic amino acids, such as polyarginine or polylysine that if necessary can be coupled with cellular ligand, for example, with carbohydrate group or transferring. The composition is used, in particular, as vaccine, for example, as vaccine against tumor. Invention provides creating vaccine with immunomodulating effect. EFFECT: valuable medicinal properties of composition. 26 cl, 1 tbl, 18 dwg, 12 ex
