FIELD: medicine.
SUBSTANCE: invention relates to Bcl-2 proteins, fragments thereof, and to application thereof in patients with a malignant tumour. The declared proteins and peptide fragments particularly are applicable in vaccine compositions for treatment of malignant tumour. Besides, the invention concerns the methods of treatment with application of specified compositions. Also, an aspect of the invention is production of T-cells and receptors thereof which are specifically recognise declared proteins and peptide fragments.
EFFECT: higher clinical effectiveness with respect to tumours.
61 cl, 5 ex, 2 tbl, 12 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| SURVIVIN PEPTIDE VACCINE | 2006 |
|
RU2396088C2 |
| MPHOSPH1 PEPTIDES AND VACCINES CONTAINING THEM | 2012 |
|
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|
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|
RU2671395C2 |
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|
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| NEIL3 PEPTIDES AND VACCINES INCLUDING SAME | 2010 |
|
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| NEIL3 PEPTIDES AND VACCINES COMPRISING THEM | 2010 |
|
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| TEM8 PEPTIDES AND VACCINES CONTAINING THEM | 2008 |
|
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| CDCA1 PEPTIDE AND PHARMACEUTICAL DRUG CONTAINING IT | 2008 |
|
RU2486195C2 |
| PEPTIDE CANCER VACCINES EXPRESSING TUMOUR-SPECIFIC ANTIGENS | 2008 |
|
RU2464275C2 |
