DERIVATIVES OF 5-THIA-ω-SUBSTITUTED PHENYLPROSTAGLANDIN E, METHODS FOR ITS PREPARING, PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new derivatives of prostaglandins, namely, to 5-thia-ω-substituted phenylprostaglandin E of the formula (I) -ω- wherein is OH or R¹-alkoxy-group; C_1-6 is oxygen or halogen atom; R² is hydrogen atom or OH; R³ and R^4a mean independently hydrogen atom or R^4b-alkyl; C_1-4 is phenyl substituted with R⁵-alkoxy-C_1-4-alkyl, C_1-4-alkenyloxy-C_2-4-alkyl, phenyloxy-C_1-4-alkyl and others. Compounds of the formula (I) can bind tightly with C_1-4-receptors (especially with receptors of subtype PGE₂). Therefore, these compounds are useful for prophylaxis and/or treatment of immunologic diseases (autoimmune diseases, such as amyotrophic lateral sclerosis, disseminated sclerosis, Sjogren's syndrome, chronic rheumoarthrosis, exanthematous (systemic) erythematosus and others, rejections after organs transplantation and others), asthma, pathology in bones formation, death of nerve cells, lung damage, liver injury, acute hepatitis, renal insufficiency, hypertension, myocardium ischemia, nephritis, general inflammatory response syndrome, burns pain, sepsis, hemophagus-syndrome, macrophages activation, Still's disease, Kawasaki's disease systemic granulomatosis, nonspecific ulcerous colitis, Crohn's disease, hypercytokinemia in dialysis, multiple organs injury, shock and others. Except for, receptor of subtype EP₄ relates to sleep disorder and blood platelet aggregation. Therefore, it is believed that proposed compounds are useful in prophylaxis and/or treatment of above indicated diseases. EFFECT: improved preparing method, valuable medicinal properties of compounds. 21 cl, 4 tbl, 5 sch, 37 ex