DERIVATIVES OF AMINOBUTYRIC, AMINOPENTANOIC AND AMINOHEXANOIC ACIDS Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to derivatives of aminobutyric, aminopentanoic and aminohexanoic acids of the general formula (I): wherein or Y-P--(OR⁵¹)₂; m = 0, 1, 2; n = O_D-3; each of R², R³, R⁴, R⁵, R⁶, R⁷ is independently hydrogen atom, C1-8-alkyl, C2-8-alkenyl, -OR¹¹, -SR¹¹, -NR¹²R¹³, Cycle 1, C1-8-alkyl substituted with -OR¹¹, -SR¹¹, -NR¹²R¹³, -COR¹⁴, guanidine or Cycle 1, or C2-8-alkenyl substituted with -OR¹¹, -SR¹¹, -NR¹²R¹³, -COR¹⁴, guanidine or Cycle 1; or R³ and R⁴, taken in common represent C1-8-alkylene; R⁵ and R⁶, taken in common represent C1-8-alkylene; R³ and R⁶ taken in common represent C1-8-alkylene; R² and R³, taken in common represent C2-8-alkylene; R⁴ and R⁵, taken in common represent C2-8-alkylene; or R⁶ and R⁷, taken in common represent C2-8-alkylene; or (1) R⁸ represents: 1) hydrogen atom; 2) C1-8-alkyl; 3) C1-8-alkoxycarbonyl; 4) C1-8-alkyl substituted with -OR²⁶, -SR²⁶, -NR²⁷R²⁸ or -COR²⁹; or 5) C1-8-alkoxycarbonyl substituted with Cycle 2; and R⁹ represents ; (2) R⁸ represents: ; R⁹ represents: 1) C1-8-alkyl; C1-8-alkoxy; 3) C1-8-alkoxy substituted with Cycle 2; 4) C1-8-alkyl substituted with -OR²⁶, -SR²⁶, -NR²⁷R²⁸, -COR²⁹ or Cycle 2, or: 5) ; A is C_3-15-mono-, bi- or tricarbocyclic or 5-18- membered mono-bi- or tri-heterocyclic ring comprising from 1 to 4 nitrogen atoms, from 1 to 2 oxygen atoms and/or from 1 to 2 sulfur atoms or its nontoxic salts and to inhibitor of matrix metalloproteinase containing compound of the formula (I) as an active component. EFFECT: valuable biochemical properties of compounds. 15 cl, 106 tbl, 73 ex