MEANS FOR LEFT VENTRICLE DIASTOLIC FUNCTION IMPROVEMENT Russian patent published in 2017 - IPC A61K31/4015 A61K47/40 A61P9/00 A61P9/04 A61P9/06 

FIELD: pharmacology.

SUBSTANCE: application of 4-[(2-{(2R)-2-((1E,3S)-4-(4-fluorophenyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]butanoic acid, or a salt thereof, of its clathrate complex with cyclodextrin for preparation of means 1) for treatment of diastolic heart failure and/or symptom alleviation; 2) for heart failure treatment, at which the diastolic function is weakened; 3) for left ventricle diastolic function improvement; 4) for left ventricle expansion improvement; 5) for left ventricle selective diastolic function improvement; 6) for diastolic functional insufficiency treatment or improvement; 7) for diastolic dysfunction treatment or improvement.

EFFECT: agent improves diastolic function of the left ventricle itself, without dependence on diuretic influence or vasodilator effect, controls the pathological state of diastolic functional insufficiency and prevents relapse, can prevent dyspnea and death caused by a pathological condition, the agent can alleviate diastolic functional failure for which an effective therapeutic method has not been established.

10 cl, 3 dwg, 5 tbl, 2 ex