THERMODYNAMICALLY RESISTANT FORM OF (R)-3-[[(4-FLUOROPHENYL)- SULFONYL]AMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID (RAMATROBAN) Russian patent published in 2003 - IPC

Abstract RU 2220137 C2

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to thermodynamically resistant form of (R)-3-[[(4-fluorophenyl)-sulfonyl]- amino] -1,2,3,4-tetrahydro- 9H-carbazole-9-propanoic acid (ramatroban) of the formula: with melting point 151 C and values of peaks maximum at 3 338 cm-1, 1 708 cm-1 and 1 431 cm-1 in IR-spectrum. Invention relates to method for its preparing that involves suspending modifying form of ramatroban 11 with melting point 137 C in water or inert organic solvents, addition of stable modifying form 1 primer and conversion at 20-50 C up to attainment of the required conversion degree. Preparing thermodynamically resistant form allows its using as a medicinal agent for control of thromboxane A2-mediated diseases. EFFECT: improved preparing method, valuable properties of compound. 9 cl, 6 dwg, 6 tbl, 6 ex

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RU 2 220 137 C2

Authors

Grunenberg Al'Fons

Vol' Karl-Khajnts

Foges Klaus-Piter

Dates

2003-12-27Published

1998-12-24Filed