FIELD: chemistry.
SUBSTANCE: invention relates to a method for prostaglandin amides preparation by general formula (I)
compounds of general formula (V)
a method for preparation of compounds of general formula (IIA)
via an intermediate lactone triol of general formula (XIII)
.
EFFECT: activated carboxylic acid derivatives of the present invention can be easily purified by crystallization to remove impurities and may also be easily converted to the desired amide final product under mild reaction conditions with high yields.
14 cl, 12 dwg
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Authors
Dates
2017-05-03—Published
2012-05-25—Filed