POLYMORPHS OF PYRROL-SUBSTITUTED 2-INDOLINONE PROTEINKINASE INHIBITORS Russian patent published in 2008 - IPC C07D403/14 A61K31/404 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention concerns polymorphs of 1-pyrrol-substituted 2-indolinone compound (2-pyrrolidine-1-ylethyl)amide 5-(5-fluor-2-oxo-1,2-dihydroindole-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-carboxylic acid, namely polymorphic form of the formula I: in the form of polymorphic form II mainly free of polymorph I characterised by PXRD powder radiogram with characteristic peaks expressed in degrees (±0.1) of double angle 7.1, 13.9, 16.0, 20.9 and 24.7, obtained with the use of CuKα₁ radiation (wavelength = 1.5406 A), and polymorphic compound form of the formula I in the form of polymorphic form I mainly free of polymorph II characterised by PXRD powder radiogram with characteristic peaks expressed in degrees (±0.1) of double angle 5.0, 16.7, 18.9, 24.8 and 27.3 obtained with the use of CuKα₁ radiation (wavelength = 1.5406 A). The invention also concerns pharmaceutical composition capable of catalytic proteinkynase activity and based on these forms, method of catalytic proteinkynase activity modeling and treatment method for patients with proteinkynase-induced diseases.

EFFECT: improved efficiency of preparations.

26 cl, 3 dwg, 4 tbl