2,5,7-SUBSTITUTED OXAZOLPYRIMIDINE DERIVATIVES Russian patent published in 2015 - IPC C07D498/04 A61K31/5383 A61P17/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to oxazolopyrimidine compounds of formula (I) , in which A is selected from NH, O and S; R¹ is selected from (C₁-C₆)-alkyl, (C₃-C₇)-cycloalkyl-C_tH_2t and Het-C_tH_2t-, where t is selected from 0, 1, 2 and 3; R² is selected from phenyl and residue of aromatic 5-member - 6-member monocyclic heterocycle, which includes 1, 2 similar or different ring heteroatoms, selected from N, O and S, in which one of ring nitrogen atoms can carry atom of hydrogen or substituent R²¹, and in which phenyl and aromatic heterocycle residue are optionally substituted in one or more ring carbon atoms with one or more similar or different substituent R²²; R³ is selected from (C₁-C₆)-alkyl, or R³ represents residue of saturated or unsaturated 3-member - 10-member, monocyclic or bicyclic ring, which includes 0, 1, 2 or 3 similar or different ring nitrogen atoms can carry hydrogen atom or (C₁-C₄)-alkyl substituent and one or two ring sulphur atoms can carry one or two oxo groups, and in which ring residue is optionally substituted in one or more ring carbon atoms with similar or different substituents R³¹, on condition that R³ cannot be (C₁-C₆)-alkyl, if A represents S; other values of radicals are given in i.1 of formula.

EFFECT: compounds of formula (I) are suitable for wound healing.

16 cl, 2 tbl, 9 ex