3-TETRAHYDROPYRIDINE-4-YLINDOLES FOR TREATMENT OF PSYCHOTIC DISORDERS Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I): wherein: R₁ represents hydrogen, halogen atom, CF₃,, (1-3C)-alkyl or CN; m = 0, 1 or 2; R₂ represents hydrogen atom or (1-3C)-alkyl; n = 3, 4, 5 or 6; R₃ represents hydrogen, halogen atom or (1-4C)-alkyl; p = 0, 1 or 2, or its pharmacologically acceptable acid- -additive salt. Compounds by cl. 1 are prepared by interaction of compound of the formula (II): with compound of the formula (III): wherein L represents removable group, such as bromine atom. Compounds by cl. 1 can be prepared also by reduction of compound of the formula (IV): wherein A represents group -(CH₂)_n-1 to corresponding compound wherein A represents group -(CH₂)_n-1-NH₂, and prepared amino- -derivative is subjected for interaction with derivative of phthalic anhydride of the formula (V): . Invention provides preparing 3-tetrahydropyridine-4-ylindoles eliciting high affinity to dopamine D₂-receptor and inhibiting reuptake of serotonin. EFFECT: improved preparing method, valuable medicinal properties of compounds. 5 cl, 1 tbl