Show metadata Hide metadata

(19)

(11)

2 273 639

(13)

(51)

IPC

C07D403/06(2006-01-01)

C07D295/73(2006-01-01)

A61K31/496(2006-01-01)

A61P25/18(2006-01-01)

(21) (22)

Application

2003136264/04, 2002-07-03

(24)

Start date

2002-07-03

(22)

Actual filing date

2002-07-03

(45)

Published

2006-04-10

(72)

Inventor

Van Marseven Jan Kh.Van Skharrenburg Gjustaf J. M.Tjulp Martinus T. M.Makkriri Ehndrju K.Ivema Bakker Vauter I.Kolen Khejn K. A. S.Kherremans Arnol'Dus Kh. J.Van Den Khogenband Adrianus

(73)

Holder

Solvej Farmas'Jutikals B.V.

DERIVATIVES OF PIPERAZINE OXIME POSSESSING ANTAGONISTIC ACTIVITY WITH RESPECT TO NEUROKININE-1 (NK-1) RECEPTOR Russian patent published in 2006 - IPC C07D403/06 C07D295/73 A61K31/496 A61P25/18

Abstract RU 2273639 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of piperazine oxime of the general formula (I): wherein X means phenyl or pyridyl substituted with 1 or 2 substitutes; Y means 2- or 3-indolyl, phenyl, 7-azaindole-3-yl, 3-indazolyl, 2-naphthyl, 3-benzo[b]thiophenyl or 2-benzofuranyl that can be substituted; n = 0-3; m = 0-2; R₁ means -NH₂, morpholino-, thiomorpholino-group, 2-, 3- or 4-pyridyl or 4-CH₃-piperazinyl. Compounds possess antagonistic activity with respect to neurokinine receptors and can be used in treatment of anxiety states. Also, invention describes a pharmaceutical composition based on compounds of the formula (I), method for its preparing and using.

EFFECT: valuable medicinal properties of compounds and composition.

7 cl, 16 ex

Similar patents RU2273639C2

Title	Year	Author	Number
DERIVATIVES OF DIAZABICYCLIC ALKANES ELICITING NK-ANTAGONISTIC ACTIVITY	2003	De Bur Dirk Kolen Khejn K. A. S. Khesselink Majkl B. Ivema Bakker Vauter I. Kejl Gejsbert D. Van Marseven Jan Kh. Makkriri Ehndrju K. Van Skharrenburg Gjustaf J. M.	RU2310656C2
HEXA- AND OCTAHYDROPYRIDO[1,2-a]PYRAZINE DERIVATIVES WITH NK-ANTAGONIST ACTIVITY	2004	Ivema Bakker Vauter I. Van Skharrenburg Gjustaf J. M. Van Den Khogenband Andrianus Makkriri Ehndrju S.	RU2349591C2
SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITION OF CATHEPSIN S ACTIVITY	2001	Kaj Kh'Jui Ehdvards Dzhejms P. Meduna Stiven P. Pajo Barbara A. Vej Dzhianmej	RU2278863C2
DERIVATIVES OF AROYLPIPERAZINE, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT	1998	Mijake Khirosi Take Kazukhiko Sigenaga Sindzi Azami Khidenori Sasaki Khirosi Eikiu Jositeru Nakai Kazuo Isida Dzunja Manabe Takasi Konisi Nobukijo Terasaka Tadasi	RU2258702C2
DERIVATIVES OF N-TRIAZOLYLMETHYLPIPERAZINE, METHOD FOR THEIR PREPARING, MEDICINAL AGENT, DERIVATIVES OF PIPERAZINE	2001	Jasserand Daniel' Shen Uve Zann Khol'Ger Brjukner Rajnkhard Ehkkhout Kristian	RU2288918C2
APOPTOSIS INDUCING AGENTS SELECTIVE FOR Bcl-2 FOR CANCER AND IMMUNE DISEASES TREATMENT	2013	Branko Milan Din Khun Douerti Dzhordzh A. Elmor Stiven V. Khasvold Liza Kheksamer Laura Kanzer Aaron R. Mantej Robert A. Makklellan Uillyam Dzh. Park Chang Kh. Park Cheol-Min Petros Endryu M. Sun Syaokhun Sauers Endryu Dzh. Sallivan Dzherard M. Tao Chzhi-Fu Van Gari T. Van Le Van Silu Uendt Majkl D.	RU2621052C2
APOPTOSIS-INDUCING PREPARATIONS FOR TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES	2009	Branko Milan Daj Judzhia Din Khun Douehrti Dzhordzh A. Ehlmor Stiven V. Khasvol'D Liza Kheksamer Laura Kanzer Aaron R. Mantej Robert A. Makklellan Uill'Jam Dzh. Park Chang Kh. Park Chehol-Min Petros Ehndrju M. Sun Sjaokhun Sauehrs Ehndrju Dzh. Sallivan Dzherard M. Tao Chzhi-Fu Van Gari T. Van Leh Van Silu Uehndt Majkl D.	RU2527450C2
BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR TREATING CANER AND IMMUNE DISEASES	2010	Branko Milan Din Khun Douehrti Dzhordzh A. Ehlmor Stiven V. Khasvol'D Liza Kheksamer Laura Kanzer Aaron Mantej Robert A. Makklellan Uill'Jam Dzh. Park Chang Kh. Park Chehol-Min Petros Ehndrju M. Sun Sjaokhun Sauehrs Ehndrju Dzh. Sallivan Dzherard M. Tao Chzhi-Fu Van Gari T. Van Leh Van Silu Uehndt Majkl D. Khansen Todd M.	RU2542994C2
INDOLES AS 5-HT MODULATORS	2007	Jokhansson Gari Angbrant Jokhan Ringom Rune Bejerlejn Katarina Khammer Kristin Ringberg Ehrik Lindkvist Bengt Brandt Peter Nil'Sson B'Ern M.	RU2449990C2
MODULATORS OF ATP-BINDING CARTRIDGE TRANSPORTERS	2005	Adida Rua Sara S. Khejzlvud Anna R. Grotenkhejs Peter D.,J. Van Gur Frederik F. Singkh Ashvani K. Chzhou Tszinlan' Makkartni Dzhejson	RU2528046C2

RU 2 273 639 C2

Authors

Van Marseven Jan Kh.

Van Skharrenburg Gjustaf J. M.

Tjulp Martinus T. M.

Makkriri Ehndrju K.

Ivema Bakker Vauter I.

Kolen Khejn K. A. S.

Kherremans Arnol'Dus Kh. J.

Van Den Khogenband Adrianus

Dates

2006-04-10—Published

2002-07-03—Filed