NOVEL PIPERIDINE SUBSTITUTED INDOLES AND HETERODERIVATIVES THEREOF Russian patent published in 2010 - IPC C07D401/04 C07D401/14 C07D413/14 C07D417/14 C07D471/04 C07D513/04 A61K31/454 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (1) and their pharmaceutically acceptable salts as chemokine receptor CCR3 activity modulators, a pharmaceutical composition based on the said compounds, to synthesis method and use thereof. Said compounds can be used for treating and preventing diseases mediated by chemokine receptor CCR3 activity, such as inflammatory and allergic diseases etc. In general formula , R¹ represents phenyl, [1,2,4]triazolo[4,3-a]pyridinyl, thiazolo [5,4-b]pyridinyl, benzothiazolyl, benzoxazolyl, pyridinyl, where each of the said phenyl or heterocycles can be substituted with one, two or three radicals R²; R² each independently represents (C₁-C₆)halogenalkyl, halogen, COOR³; CONR³R⁴; R³ represents H or (C₁-C₆)alkyl; R⁴ represents H or (C₁-C₆)alkyl, R⁵ represents (C₁-C₆)alkyl, (C₁-C₆)alkoxy, (C₃-C₆)cycloalkyl; R⁶ each independently represents (C₁-C₆)alkoxy, (C₁-C₆)halogenalkyl, halogen, OR³, CN, CONR³R⁴; A represents C(CH₃)₂-CH₂-CH₂-, CH₂-CH₂-CH₂- or B represents phenyl; D-E represents CH-CH₂- or C=CH-, X-W-V represents N-C=CR⁷ or C=C-NR⁷; R⁷ represents H or (C₁-C₆)alkyl; Y represents NR⁴, O, S(O)n; i, j, m each equals 1, n equals 0 or 2.

EFFECT: increased effectiveness of using said compounds.

13 cl, 37 ex