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2 223 788

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(51)

IPC

(21) (22)

Application

2002103465/15, 1997-03-27

(24)

Start date

1997-03-27

(22)

Actual filing date

1997-03-27

(45)

Published

2004-02-20

(72)

Inventor

Gjuntsburg Val'Ter Kh.Karle PeterZaller Robert Mikhel'

(73)

Holder

Bavarian Nordik Riserch Instit'Jut A/SGsf-Forshungstsentrum Fjur Umvel'T Und Gezundkhajt Gmbkh

CYTOCHROME P-450-TRANSDUCING RETROVIRAL VECTORS Russian patent published in 2004 - IPC

Abstract RU 2223788 C2

FIELD: medicine, oncology, biochemistry, pharmacy. SUBSTANCE: invention relates to medicinal preparations, in particular, retroviral vectors transducing cytochrome P-450. Invention involves pharmaceutical composition for carrying out an anti-tumor therapy and representing capsule, encapsulating cell comprising gene that expresses cytochrome P-450. Capsule comprises porous membrane that is permeable for prodrug molecules that is activated with cytochrome P-450 and converted to an active metabolite. The advantage of invention is the development of new replicatively defective retroviral vectors carrying gene encoding cytochrome P-450. EFFECT: valuable properties of vectors. 7 cl, 5 ex

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RU 2 223 788 C2

Authors

Gjuntsburg Val'Ter Kh.

Karle Peter

Zaller Robert Mikhel'

Dates

2004-02-20—Published

1997-03-27—Filed