FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazoline-2-yl] methoxy] benzyl] -thiazolidine-2,4-dione of the formula (I) 
. Method involves reduction of compound of the formula (2') 
wherein R means (C1-C4) alkyl group using Raney nickel or magnesium and if necessary the repeated esterification using sulfuric acid in the range of temperature from 0C to 60 C to yield compound of the formula (3') 
that is subjected for hydrolysis to yield acid of the formula (4) 
followed by condensation of acid of the formula (4) with N-methylanthranylamide of the formula (7) 
without any preliminary activation of acid to yield compound of the formula (I) that if necessary is converted to pharmaceutically acceptable salt. Invention relates also to method for preparing compound of the formula (2') involving interaction of p-hydroxybenzaldehyde of the formula (10) 
with alkylhaloacetate of the formula (11) 
wherein Hal means halogen atom and R means (C1-C4)-alkyl in the presence of aromatic hydrocarbon solvent, base, alkylor arylsulfonic acid and iodine to yield compound of the formula (12) 
that is subjected for condensation with thiazolidine-2,4-dione of the formula (13) 
in the presence of absence of a solvent and using catalyst to yield compound of the formula (2'). EFFECT: improved preparing method of derivatives of thiazolidine-2,4-dione. 36 cl, 40 ex
| Title | Year | Author | Number |
|---|---|---|---|
| POLYMORPHOUS CRYSTALLINE FORMS OF 5-[4-[2-[N-METHYL-N-(2-PYRIDYL)-AMINO]-ETHOXY]-BENZYL]-THIAZOLIDINE-2,4-DIONE MALEATE | 2001 |
|
RU2286345C2 |
| SUBSTITUTED CONDENSED HETEROCYCLIC COMPOUND, METHOD OF PHARMACOLOGICAL EFFECT, METHOD OF INHIBITION OF 5-LIPOXYGENASE ACTIVITY, INHIBITION OF LIPID PEROXIDES PRODUCTION OR BLOOD SUGAR LEVEL DECREASE | 1998 |
|
RU2196141C2 |
| THIAZOLIDEN-2,4-DIONE DERIVATIVE, PROCESS FOR PREPARATION THEREOF, THIAZOLIDIN-2,4-DIONE DERIVATIVE AS INTERMEDIATE PRODUCT WHEN PREPARING AROMATIC AMINOALCOHOL DERIVATIVES | 1994 |
|
RU2081113C1 |
| THIAZOLIDINE COMPOUNDS, METHOD OF PREPARATION THEREOF, METHOD OF REDUCING SUGAR CONTENT IN BLOOD OF MAMMALS | 1992 |
|
RU2095354C1 |
| NOVEL DERIVATIVES OF AZOLIDINEDIONE, METHOD OF THEIR SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF, METHOD OF PROPHYLAXIS OR TREATMENT, METHOD OF GLUCOSE LEVEL DECREASE AND INTERMEDIATE COMPOUND | 1997 |
|
RU2200161C2 |
| BETA-ARYL-ALPHA-HYDROXY-SUBSTITUTED ALKYLCARBOXYLIC ACIDS, METHODS FOR THEIR PREPARING, INTERMEDIATE COMPOUNDS, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATMENT OR PROPHYLAXIS OF DISEASES BASED ON NEW COMPOUNDS | 1998 |
|
RU2235094C2 |
| PROCESS FOR PREPARATION OF TENELIGLIPTIN | 2013 |
|
RU2654069C2 |
| OXAZOLIDINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS AND METHOD OF THEIR SYNTHESIS | 1993 |
|
RU2090564C1 |
| METHOD FOR PREPARING PIOGLITAZONE AS ANTIDIABETIC AGENT | 2002 |
|
RU2281285C2 |
| INHIBITORS OF CELLULAR ADHESION MEDIATED BY αβ-INTEGRINS | 2003 |
|
RU2315768C2 |
