INHIBITORS OF CELLULAR ADHESION MEDIATED BY αβ-INTEGRINS Russian patent published in 2008 - IPC C07D487/04 A61K31/4188 A61P29/00 

Abstract RU 2315768 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to a novel compound of the general formula (I): wherein R means hydrogen atom (H), -OH, carbamoyl group; n = 1 or 2, or to its pharmaceutically acceptable salt. Compounds of the formula (I) are potential inhibitors of cellular adhesion mediated by integrins that allows its using as components of pharmaceutical composition used in treatment or prophylaxis of inflammatory, autoimmune or allergic state or rejection mediated by LFA-1.

EFFECT: valuable medicinal properties of compound and pharmaceutical composition.

19 cl, 2 sch, 3 dwg, 3 tbl, 7 ex

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RU 2 315 768 C2

Authors

Sirkar Ila

Morningstar Marshall

Kakushima Masatoshi

Kadzi Khidefumi

Kavaguti Takajuki

Kume Toshijuki

Dates

2008-01-27Published

2003-02-06Filed