CEPHEM DERIVATIVES, METHOD FOR THEIR PREPARING, COMPOUND, PHARMACEUTICAL COMPOSITION, TREATMENT METHOD Russian patent published in 2004 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy, antibiotics. SUBSTANCE: invention relates to cephem derivatives of the formula (I) eliciting the broad spectrum of anti- bacterial activity with respect to different pathogenic microorganisms species including MRS A wherein X means nitrogen atom or CY wherein Y means hydrogen or halogen atom; R¹ means amino-group or protected amino-group; R² means hydrogen atom or optionally substituted (lower)alkyl; R³ means hydrogen atom or lower alkyl; R⁴ means hydrogen atom, hydroxy-group, optionally substituted (lower)alkyl or alkenyl, or lower alkoxy-group, optionally substituted N-containing heterocyclic group; R⁵ means hydrogen atom, lower alkyl that can be substituted; or R⁴ and R⁵ can form lower alkylene with possibly embedded heteroatom; wavy line means syn-isomer or mixture of isomers; salts or solvates. Invention describes method for their preparing also. EFFECT: improved preparing method. 24 cl, 16 tbl, 34 ex