FIELD: medicine, pharmacy. SUBSTANCE: invention relates to a solid dosed medicinal formulation for oral administration including the combination of metformin and glibenclamide wherein glibenclamide particles size provides bioavailability of glibenclamide that is comparable with that of glibenclamide providing by administration of metformin and glibenclamide as separate tablets. EFFECT: enhanced effectiveness of medicinal formulation. 7 cl, 7 tbl, 3 dwg, 3 ex _
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