TETRACHLOROPHTHALIC ACID 4-METHYL-2-PYRIDYLAMIDE ELICITING HYPERTENSIVE ACTIVITY Russian patent published in 2004 - IPC

Abstract RU 2227797 C2

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to dicarboxylic acid amides, namely, to a new biologically active tetrachlorophthalic acid 4-methyl-2-pyridylamide of the formula: . The compound is prepared by interaction of 4-methyl-2-aminopyridine with tetrachlorophthalic acid anhydride. The compound represents white crystalline substance that is soluble in water, ethanol, DMFA (dimethylformamide), DMSO (dimethylsulfoxide) with value T_m = 200-201 C. The compound elicits hypertensive activity and enhances arterial blood pressure reliably in anesthetized cats in the dose 5.15 mg/kg (0.1 LD₅₀) in intravenous administration by 51 ± 8.1 mm of mercury column and acts for 60 min. Value LD₅₀ in intravenous administration to white mice for this compound is 51.5 (45.0-69.0) mg/kg. EFFECT: valuable medicinal property of compound. 1 cl, 1 tbl, 1 dwg

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RU 2 227 797 C2

Authors

Dolzhenko A.V.

Kolotova N.V.

Koz'Minykh V.O.

Syropjatov B.Ja.

Dates

2004-04-27—Published

2002-03-29—Filed