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2 294 199

(13)

(51)

IPC

A61K31/44(2006-01-01)

A61P7/02(2006-01-01)

C07D213/75(2006-01-01)

(21) (22)

Application

2005113025/04, 2005-04-28

(24)

Start date

2005-04-28

(22)

Actual filing date

2005-04-28

(45)

Published

2007-02-27

(72)

Inventor

Kolotova Nina Vasil'EvnaSyropjatov Boris JakovlevichDolzhenko Anton VladimirovichIsmajlova Natal'Ja Gennad'Evna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Farmatsevticheskaja Akademija Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju" Vpo Pgfa Roszdrava)

MALEIC ACID 3-METHYL-2-PYRIDYLAMIDE ELICITING DIRECT ANTICOAGULANT EFFECT Russian patent published in 2007 - IPC A61K31/44 A61P7/02 C07D213/75

Abstract RU 2294199 C2

FIELD: organic chemistry, chemical technology, medicine, hematology.

SUBSTANCE: invention relates to using maleic acid 3-methyl-2-pyridylamide of the formula: in medicine as an anticoagulant agent. Compound is synthesized by interaction of 2-amino-3-methylpyridine with maleic anhydride. Synthesized compound is a white crystalline substance with value T_m = 136-137°C and soluble in water, ethanol, dimethylformamide (DMFA) and dimethylsulfoxide (DMSO). Synthesized substance provides increasing coagulating time of citrate blood and percent for coagulating capacity change in the concentration of this substance 1 mg/ml and 0.5 mg/ml by 502.4% and 92.2%, respectively. Value LD₅₀ for this substance is 20.5 (12.2-31.3) mg/kg after its intravenous injection in white mice.

EFFECT: valuable medicinal property of compound.

1 tbl

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RU 2 294 199 C2

Authors

Kolotova Nina Vasil'Evna

Syropjatov Boris Jakovlevich

Dolzhenko Anton Vladimirovich

Ismajlova Natal'Ja Gennad'Evna

Dates

2007-02-27—Published

2005-04-28—Filed