MALEIC ACID 4-METHYL-2-PYRIDYLAMIDE ELICITING HYPERTENSIVE ACTIVITY Russian patent published in 2005 - IPC

Abstract RU 2247721 C2

FIELD: organic chemistry, chemical technology, medicine.

SUBSTANCE: invention relates to a new biologically active compound representing maleic acid 4-methyl-2-pyridylamide of the formula: . Compound is synthesized by interaction of 4-methyl-2-aminopyridine with maleic anhydride. Compound represents white crystalline substance soluble in water, dimethylformamide (DMFA) and dimethylsulfoxide (DMSO) with value T_m = 146^oC. Compound elicits the hypertensive activity elevating arterial pressure value in narcotized cats after intravenous administration in the dose 5 mg/kg (about 0.1 LD₅₀) by 60.4 ± 8.23 mm mercury column reliably and acts for 90 min. Value LD₅₀ in intravenous administration to white mice is 44.7 (39-50) mg/kg.

EFFECT: valuable medicinal properties of compound.

1 cl, 1 tbl, 1 ex

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RU 2 247 721 C2

Authors

Dolzhenko A.V.

Kolotova N.V.

Koz'Minykh V.O.

Syropjatov B.Ja.

Dates

2005-03-10—Published

2003-05-15—Filed