Show metadata Hide metadata

(19)

(11)

2 264 390

(13)

(51)

IPC

(21) (22)

Application

2004128877/04, 2004-09-29

(24)

Start date

2004-09-29

(22)

Actual filing date

2004-09-29

(45)

Published

2005-11-20

(72)

Inventor

Bukanova E.V.Igidov N.M.Makhmudov R.R.Borodin A.Ju.Zakhmatov A.V.

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Farmatsevticheskaja Akademija Ministerstva Zdravookhranenija Rossijskoj Federatsii" Vpo Minzdrava Rossii")Permskij Gosudarstvennyj Universitet

2-HYDROXY-5,5-DIMETHYL-4-OXO-2-HEXENOIC ACID N-41-METHYL-21-PYRIDYLAMIDE ELICITING HYPERTENSIVE ACTIVITY Russian patent published in 2005 - IPC

Abstract RU 2264390 C1

FIELD: organic chemistry, chemical technology, medicine.

SUBSTANCE: invention relates to a new compound - 2-hydroxy-5,5-dimethyl-4-oxo-2-hexenoic acid N-4¹-methyl-2¹-pyridylamide of the formula:

. This compound is prepared by interaction of 2-hydroxy-5,5-dimethyl-4-oxo-2-hexenoic acid with 4-methyl-2-pyridylamine. Proposed compound can be used in medicine as a hypertensive agent. The hypertensive activity of this compound exceeds activity of standard compound - midodrine hydrochloride by 2-fold increase of arterial pressure value and by 3-fold by duration effect in combination with 2-fold reduced toxicity.

EFFECT: improved and valuable medicinal properties of compound.

1 cl, 2 tbl, 1 ex

Similar patents RU2264390C1

Title	Year	Author	Number
MALEIC ACID 4-METHYL-2-PYRIDYLAMIDE ELICITING HYPERTENSIVE ACTIVITY	2003	Dolzhenko A.V. Kolotova N.V. Koz'Minykh V.O. Syropjatov B.Ja.	RU2247721C2
TETRACHLOROPHTHALIC ACID 4-METHYL-2-PYRIDYLAMIDE ELICITING HYPERTENSIVE ACTIVITY	2002	Dolzhenko A.V. Kolotova N.V. Koz'Minykh V.O. Syropjatov B.Ja.	RU2227797C2
N-ISOPROPYLAMIDE 2-(6,7-DIMETHOXY-3-SPIRO-CYCLOPENTYL-3,4-DIHYDROISOQUINOLYL-1)-ETHANOIC ACID HYDROCHLORIDE, WHICH POSSESSES HYPERTENSIVE ACTIVITY	2010	Limanskij Evgenij Sergeevich Rudakova Irina Pavlovna Mikhajlovskij Aleksandr Georgievich Syropjatov Boris Jakovlevich Vakhrin Mikhail Ivanovich	RU2491277C2
N-(1,3-TIAZOL-2-YL)AMIDES OF 2-DIPHENYLMETHYLENEHYDRAZONO-5,5-DIMETHYL-2,4-DIOXOHEXANE ACID, DEMONSTRATING ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY AND METHOD OF OBTAINING	2007	Igidov Nazim Musabekovich Makhmudov Ramiz Ragibovich Fedorovtseva Anastasija Nikolaevna	RU2345072C1
MALEIC ACID 3-METHYL-2-PYRIDYLAMIDE ELICITING DIRECT ANTICOAGULANT EFFECT	2005	Kolotova Nina Vasil'Evna Syropjatov Boris Jakovlevich Dolzhenko Anton Vladimirovich Ismajlova Natal'Ja Gennad'Evna	RU2294199C2
1,4,5,6-TETRAHYDRO-6-OXO-5-(2-PIPERAZINOETHYL)-4-PHENYL-3-(4-CHLOROPHENYL)PYRROLO[3.4-C]PYRAZOLE DIHYDROCHLORIDE ELICITING HYPOTENSIVE AND ANTI-COAGULANT ACTIVITY	2006	Gejn Vladimir Leonidovich Syropjatov Boris Jakovlevich Kasimova Natal'Ja Nurislamovna Dozmorova Natal'Ja Viktorovna Egorova Anastasija Olegovna Ismajlova Natal'Ja Gennad'Evna	RU2320661C2
BIS{3-PHENYL-1-[N-(3-PYRIDYL)CARBOXAMIDO]-1,3-PROPANDIONATO} CADMIUM, WHICH HAS ANTI-FLAMMATORY ACTIVITY	2007	Pulina Natal'Ja Alekseevna Jushkov Vladimir Viktorovich Mokin Pavel Aleksandrovich Zalesov Vladimir Vasil'Evich Jatsenko Konstantin Vjacheslavovich	RU2342364C1
N-(2-THIAZOLYL)AMIDE OF 2-(2-OXO-3-INDOLINYLIDENE)HYDRAZINO-4-OXO-4-PHENYL-2-BUTENOIC ACID HAVING ANTIBACTERIAL AND ANALGESIC ACTIVITY	2008	Pulina Natal'Ja Alekseevna Jushkov Vladimir Viktorovich Sobin Fedor Vladimirovich Odegova Tat'Jana Fedorovna Vakhrin Mikhail Ivanovich Jatsenko Konstantin Vjacheslavovich Fedorenko Elena Nikolaevna	RU2401837C2
4-ARYL-2-HYDROXY-4-OXO-3-(2-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINYL)-2-BUTENOIC ACID TRIAZYLAMIDES ELICITING ANTI-INFLAMMATORY ACTIVITY	2001	Mashevskaja I.V. Anikina L.V. Vikharev Ju.B. Safin V.A. Kol'Tsova S.V. Maslivets A.N.	RU2199537C1
4-HYDROXY-5-(3-NITROPHENYL)-4-(4-CHLOROBENZOYL)-1-(2-DIETHYLAMINOETHYL)-3-PYRROLINE-2-ONE HYDROCHLORIDE ELICITING ANTI-INFLAMMATORY ACTIVITY	2005	Gejn Vladimir Leonidovich Jushkov Vladimir Viktorovich Kasimova Natal'Ja Nurislamovna Shuklina Natal'Ja Sergeevna Gubanova Marina Vladimirovna	RU2303448C2

RU 2 264 390 C1

Authors

Bukanova E.V.

Igidov N.M.

Makhmudov R.R.

Borodin A.Ju.

Zakhmatov A.V.

Dates

2005-11-20—Published

2004-09-29—Filed