METHOD FOR PREPARING 4,4-DIMETHYL-1-(PARA-CHLOROPHENYL)-PENTANE-3-ONE Russian patent published in 2004 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing 4,4-dimethyl-1-(p-chlorophenyl)-pentane-3-one that is an intermediate compound used for preparing pesticides and pharmaceutical substances, among them, tebuconazole. Method involves condensation of pinacolin with p-chlorobenzaldehyde in butyl alcohol an aqueous medium in the presence of alkali. Hydrogenation process is carried out in melt of the prepared 4,4-dimethyl-1-(p- chlorophenyl)-pent-1-ene-3-one in the presence Ni-Re as a catalyst. Method provides carrying out the hydrogenation process with the increased rate and in reduced consumption of catalyst and provides reducing formation of by-side products. EFFECT: improved preparing method. 4 cl, 1 tbl, 5 ex