FIELD: medicine, pharmacy. SUBSTANCE: invention relates to composition of recombinant proteins, method for preparing the composition, pharmaceutical kit of reagents used in immunotherapy and prophylactic vaccination of tumor diseases in anus-genital sphere and method for immunotherapy and prophylactic vaccination. Invention involves hybrid proteins consisting of amino acid sequences of oncoprotein E7 of human papilloma virus of 16 and 18 types that are bound covalently with amino acid sequence of heat shock protein with molecular mass 70 kDa (Hsp70) from M. tuberculosis - E716-Hsp70 and E718-Hsp70, respectively. EFFECT: enhanced activity of composition. 6 cl, 5 dwg, 7 ex
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