METHOD FOR PREDICTING PRENEOPLASTIC COMPLICATIONS OF GASTROESOPHAGEAL REFLUX DISEASE Russian patent published in 2004 - IPC

FIELD: medicine, surgery, oncology, gastroenterology, medicinal microbiology. SUBSTANCE: the present innovation is carried out due to performing fibroesophagogastroscopy with biopsy. Moreover, sampling of bioptates should be conducted from esophageal mucus being distally against the toothed line to carry out bacteriological trial of bioptates for the presence of Helicobacter pylori. In isolated culture one should detect antilysozyme activity and at the level of this factor being either equal or above 2 mcg/ml it is possible to diagnose preneoplastic complication of gastroesophageal reflux disease. The method enables to reveal the disease at its earlier stage when clinical symptoms and endoscopic signs are absent, carry out additional methods of investigation in due time, begin adequate treatment. This method is simple and requires no expensive equipment. EFFECT: higher efficiency of diagnostics. 1 cl, 3 ex, 1 tbl