PHARMACEUTICAL COMPOSITION ELICITING WITH ANTIBACTERIAL EFFECT AND METHOD FOR IT PREPARING Russian patent published in 2004 - IPC

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to a pharmaceutical composition with an antibacterial effect and comprising core covered by film-forming envelope where core comprises ofloxacin taken in the effective dose and the following special additions: microcrystalline cellulose, starch, polyvinylpyrrolidone and stearate. Film-forming envelope comprises hydroxypropylmethylcellulose, titanium dioxide and Tween-90 or polyethylene glycol or glycerol triacetate. Invention relates also to a method for preparing the indicated composition that involves wet granulation of mixture of ofloxacin with microcrystalline cellulose, all amount or part of starch and polyvinylpyrrolidone and the following drying, powdering dried granules, tableting the final mixture and its applying on the prepared cores of envelope. Composition elicits with the enhanced bioavailability and prolonged fitness period.

EFFECT: improved preparing method, valuable pharmaceutical properties of composition.

13 cl, 1 tbl, 3 ex