PHARMACEUTICAL COMPOSITION WITH ANTIBACTERIAL ACTIVITY AND METHOD FOR ITS PREPARING Russian patent published in 2004 - IPC

FIELD: medicine, pharmaceutical technology, pharmacy. SUBSTANCE: composition contains roxithromycin as a therapeutically active component and the following special additions: microcrystalline cellulose, primogel, hydroxypropylcellulose and stearate. Tablet-core is covered with film-forming envelope made of mixture of hydroxypropylmethylcellulose, polyethylene glycol, glycerol, talc and titanium dioxide or of ready mixture "Opadry" of the firm "Colorcon" (USA) based on hydroxypropylmethylcellulose. Method for making tablets is carried out by wetting granulation and the following covering tablet-core with film-forming composite. Roxithromycin tablets with cover satisfy all requirements of The State Pharmacopoeia XI, they release active substance easily that provides high bioavailability of roxithromycin. Fitness time for roxithromycin tablets is above two years. EFFECT: improved preparing method, valuable pharmaceutical properties of tablets. 7 cl, 1 tbl, 5 ex