FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and chemical-pharmaceutical industry, namely to a pharmaceutical composition of levofloxacin. The technical result is ensured by using Klucel and a combination of desintegrants, including sodium starch glycolate and sodium croscarmellose in the composition, with the first desintegrant being introduced before wet granulation, and the second one - after dry granulation together with an antifriction agent that is magnesium stearate.
EFFECT: composition possesses a better combination of bioavailability and appearance of tablets, including in storage; as additives, the composition contains microcrystalline cellulose (MCC), sodium starch glycolate, sodium croscarmellose, calcium carbonate, hydroxypropyl cellulose and stearic acids and/or salts thereof.
10 cl, 8 ex, 4 tbl
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