FIELD: pharmacy.
SUBSTANCE: group of inventions is proposed: application of catechol-O-methyltransferase (COMT) tolcapone, entacapone or nitecapone inhibitor for prevention and/or treatment of transthyretin-associated amyloidosis; application of the same compound for manufacture of a medicament for the same purpose; application of the combination of the same compound and an additional medicament selected from the other said COMT inhibitor, or benzoxazole, iodine diflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxycycline and epigallocatechin-3-gallate derivative, for manufacture of a medicament for the same purpose; application of a therapeutic agent selected from the group consisting of benzoxazole, iodine diflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxycycline and epigallocatechin-3-gallate derivative, for manufacture of a medicament for prevention and/or treatment of transthyretin-associated amyloidosis in combination therapy with a COMT tolcapone, entacapone or nitecapone inhibitor for prevention and/or treatment of transthyretin-associated amyloidosis.
EFFECT: stabilization of transthyretin tetramer and disintegration of transthyretin fibrils.
13 cl, 4 dwg, 6 tbl
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