OPTICALLY PURE ANALOGUES OF CAMPTOTHECIN, OPTICALLY PURE INTERMEDIATE PRODUCT OF SYNTHESIS AND METHOD FOR ITS PREPARING Russian patent published in 2004 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to compounds represented by formulas (I)

,

(II)

and (III)

.

Invention proposes compound of the formula (M)

as an intermediate product wherein R means ethyl radical. Invention proposes a method for preparing compound of the formula (M). Invention proposes a medicinal agent eliciting anti-tumor activity that comprises compounds of the formula (I), (II) or (III), or their salts with pharmaceutically acceptable mineral or organic salts. Also, invention proposes a pharmaceutical composition eliciting an anti-tumor activity and containing an active component and pharmaceutically acceptable vehicle. As an active component the pharmaceutical composition contains compounds of the formula (I), (II) or (III). Invention provides preparing camptothecin analogues eliciting anti-proliferative activity with regards to cancer cells.

EFFECT: improved preparing method, valuable medicinal properties of compounds.

9 cl, 1 tbl, 3 ex