VETERINARY COMBINATION AND METHOD FOR FLEA CONTROL Russian patent published in 2004 - IPC

FIELD: organic chemistry, insecticides.

SUBSTANCE: invention relates to veterinary science and can be used for control of fleas. Veterinary composition used for control of fleas comprises compound of the formula (I): that is effective against fleas and wherein R₁ means hydrogen atom, (C₁-C₆)-alkyl or (C₃-C₇)-cycloalkyl; R₂ means hydrogen atom, (C₁-C₆)-alkyl or (C₃-C₇)-cycloalkyl; R₃ means hydrogen atom or (C₁-C₆)-alkyl; A means unsubstituted heterocyclyl or substituted with one or some similar or different halogen atoms; and compound of the formula (II): wherein X means halogen atom; X₁ means hydrogen or halogen atom; X₂ means hydrogen or halogen atom; Y means partially or completely halogenated (C₁-C₆)-alkyl or completely halogenated (C₁-C₆)-alkyl wherein its chain comprises oxygen atom, or partially or completely halogenated (C₂-C₆)-alkenyl; Y₁ means hydrogen or halogen atom; Y₂ means hydrogen or halogen atom; Y₃ means hydrogen or halogen atom; Z₁ means hydrogen atom or (C₁-C₃)-alkyl; Z₂ means hydrogen atom or (C₁-C₃)-alkyl, and physiologically acceptable excipient for the combination. Method for control fleas in domestic animals and involves systemic administration of combination to domestic animal by cl. 1 in the effective dose against fleas and the combination is administrated by oral route. Compound of the formula (I) and compound of the formula (II) are administrated as separated dosed form but simultaneously to one another or compound of the formula (I) is administrated firstly followed by treatment with compound of the formula (II). Invention provides death of 99-100% of fleas.

EFFECT: valuable insecticide properties of combination.

5 cl, 3 tbl, 9 ex