DISPERSABLE MICROPARTICLES STABILIZED WITH PHOSPHOLIPID Russian patent published in 2004 - IPC

FIELD: pharmaceutical industry and technology.

SUBSTANCE: invention relates to rapidly dispersable, solid, dry, therapeutic, dosed formulation consisting of water-insoluble compound existing as nanomeric or micromeric solid particles with their surface stabilized with phospholipid being particles of solid substance are dispersed in volume-forming matrix. After addition of the dosed formulation to an aqueous medium the volume-forming matrix is dissolved completely essentially for 2 min releasing thus particles of water-insoluble solid substance in non-aggregated and/or non-agglomerated state. The dosed form consists of water-insoluble substance or therapeutically useful water-insoluble or difficultly water-soluble compound, phospholipid and also, optionally, at least one non-ionic, anionic, cationic or amphipathic surface-active substance in common with matrix or volume-forming substance and, if necessary, releasing agent. An average volume-weight size of water-insoluble particles is 5 mcm or less.

EFFECT: valuable pharmaceutical properties of microparticles.

10 cl, 1 tbl