FIELD: pharmaceutics. SUBSTANCE: invention relates to substances of submicrometer size or other water-insoluble or difficultly water-soluble substances that are produced by using a combination of one or more surface-active substance as a surface modifying agent, for example, polaxomers, poloxamines, polyoxyethylene sorbitol and saturated acid esters and similar with natural or synthetic phospholipids. Obtained particles show average-weighted by volume size but two-fold smaller as compared with particles obtained with phospholipid using only. Prepared composites are stable with respect to increase of particles size at storage. EFFECT: enhanced stability of composites at storage. 16 cl, 4 tbl
| Title | Year | Author | Number |
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