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2 233 842

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IPC

(21) (22)

Application

2003100974/04, 2003-01-13

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Start date

2003-01-13

(22)

Actual filing date

2003-01-13

(45)

Published

2004-08-10

(72)

Inventor

Petrov V.I.Ozerov A.A.Novikov M.S.Pokrovskij V.I.Pokrovskij V.V.De Klerk EhrikBal'Zarini Jan

(73)

Holder

Petrov Vladimir IvanovichOzerov Aleksandr AleksandrovichNovikov Mikhail StanislavovichPokrovskij Valentin IvanovichPokrovskij Vadim ValentinovichDe Klerk EhrikBal'Zarini Jan

DERIVATIVES OF PURINE ELICITING ANTIVIRAL ACTIVITY Russian patent published in 2004 - IPC

Abstract RU 2233842 C1

FIELD: organic chemistry, heterocyclic compounds.

SUBSTANCE: invention relates to derivatives of purine eliciting an antiviral activity with respect to human cytomegalovirus and human immunodeficiency virus type-1 of the general formula (I): wherein n = 0-4; m = 0-3; R¹ means hydrogen atom, hydroxyl or NH₂-group; R² means hydroxyl, NH₂-group, acetylamino-group or benzoylamino-group; R³ means hydrogen atom or lower (C₁-C₄)-alkyl; R⁴ means hydrogen atom, lower (C₁-C₄)-alkyl or phenyl; X means CH, oxygen atom, NH or C(O)O; Y means CH₂, CH=CH, C(O), oxygen atom or a simple bond; Ar means phenyl, pyridyl, naphthyl or substituted phenyl of the formula: wherein R⁵-R⁹ mean independently (C₁-C₈)-alkyl, (C₅-C₆)-cycloalkyl, 1-adamantyl, allyl, phenyl, benzyl, fluorine, chlorine, bromine, iodine atom, trifluoromethyl group, (C₁-C₅)-alkoxy-group, phenoxy-group, benzyloxy-group, cyano-group, carboxy-group, acetyl or nitro-group. Antiviral effect of the most active substances with respect to human cytomegalovirus in vitro elicits in concentrations 0.01-0.0005 μM and shows selectivity index 1 000-400 000.

EFFECT: valuable medicinal antiviral properties of compounds.

1 cl, 5 tbl, 2 ex

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RU 2 233 842 C1

Authors

Petrov V.I.

Ozerov A.A.

Novikov M.S.

Pokrovskij V.I.

Pokrovskij V.V.

De Klerk Ehrik

Bal'Zarini Jan

Dates

2004-08-10—Published

2003-01-13—Filed