5-SUBSTITUTED HIV-INHIBITING PYRIMIDINES Russian patent published in 2011 - IPC C07D239/48 C07D239/50 A61K31/505 A61P31/18 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel 5-substituted pyrimidines of general formula (I), their pharmaceutically acceptable additive salts probably in form of their stereochemically isomeric form. In general formula (I), A represents -CH₂-CH₂-, -CH=CH-; each of R¹ independently represents hydrogen; R² represents cyano; X₁ represents -NR¹-; R³ represents H, C_1-6-alkyl, halogen; R⁴ represents H, C_1-6-alkyl, halogen; R⁵ represents nitro, amino, mono- and di(C_1-4-alkyl)amino, phenyl, probably substituted by halogen, halogen, -CO-H-, -COOR⁷, -NH-C(=O)H, -NH-C(=O)R⁶, -CH=N-O-R⁸; R⁶ represents C_1-4-alkyl, amino, mono- or di(C_1-4-alkyl)amino or polyhalogen-C_1-6-alkyl; R⁷represents hydrogen, C_1-6-alkyl; R⁸ represents hydrogen, C_1-6-alkyl. Invention also relates to pharmaceutical composition based on novel compounds.

EFFECT: elaborated are compounds which possess antiviral activity with respect to HIV infection.

7 cl, 2 tbl, 33 ex