Show metadata Hide metadata

(19)

(11)

2 489 427

(13)

(51)

IPC

C07D239/54(2006-01-01)

C07D239/553(2006-01-01)

A61K31/513(2006-01-01)

A61P31/18(2006-01-01)

(21) (22)

Application

2012130760/04, 2012-07-18

(24)

Start date

2012-07-18

(22)

Actual filing date

2012-07-18

(45)

Published

2013-08-10

(72)

Inventor

Petrov Vladimir IvanovichOzerov Aleksandr AleksandrovichLuganchenko Andrej Igorevich

(73)

Holder

Petrov Vladimir IvanovichOzerov Aleksandr AleksandrovichLuganchenko Andrej Igorevich

PYRIMIDINE DERIVATIVES OF BENZOPHENONE, HAVING ANTI-HIV-1 ACTIVITY Russian patent published in 2013 - IPC C07D239/54 C07D239/553 A61K31/513 A61P31/18

Abstract RU 2489427 C1

FIELD: biotechnologies.

SUBSTANCE: invention relates to new non-nucleoside inhibitors of virus reproduction representing pyrimidine derivatives of benzophenon: 1-[2-(2- benzoylphenoxy)ethyl]uracyls corresponding to a structural formula: where: R¹ =H, CH₃, F, Br; R²=H, CH₃.

EFFECT: new compounds do not contain additional substitutes in aromatic nuclei of a benzophenone fragment and show anti-HIV-1 activity in vitro, which exceeds activity of nevirapine and matches activity of efavirenz.

3 tbl, 3 ex

Similar patents RU2489427C1

Title	Year	Author	Number
METHODS FOR INCREASING SOLUBILITY OF MEDICINAL AGENT BASED ON PYRIMIDINE DERIVATIVE OF BENZOPHENONE	2019	Makarov Valerij Gennadevich Makarova Marina Nikolaevna Demchenko Dmitrij Valentinovich	RU2729792C1
METHOD FOR PRODUCING MONOSUBSTITUTED DERIVATIVES OF URACIL	2017	Ozerov Aleksandr Aleksandrovich Novikov Mikhail Stanislavovich	RU2648998C1
DERIVATIVES OF PURINE ELICITING ANTIVIRAL ACTIVITY	2003	Petrov V.I. Ozerov A.A. Novikov M.S. Pokrovskij V.I. Pokrovskij V.V. De Klerk Ehrik Bal'Zarini Jan	RU2233842C1
QUINAZOLINE DERIVATIVES, POSSESSING ANTIDEPRESSANT, ANXIOLYTIC AND NOOTROPIC ACTIVITY	2012	Petrov Vladimir Ivanovich Tjurenkov Ivan Nikolaevich Ozerov Aleksandr Aleksandrovich	RU2507199C1
QUINAZOLINE DERIVATIVES, POSSESSING NOOTROPIC AND ANTIHYPOXIC ACTIVITY	2012	Petrov Vladimir Ivanovich Tjurenkov Ivan Nikolaevich Ozerov Aleksandr Aleksandrovich	RU2507198C1
DERIVATIVES OF QUINAZOLINE-4 (3H)-ONE, WITH NEURO- AND CARDIOPROTECTIVE ACTIVITY	2016	Petrov Vladimir Ivanovich Tyurenkov Ivan Nikolaevich Ozerov Aleksandr Aleksandrovich Novikov Mikhail Stanislavovich Perfilova Valentina Nikolaevna Kurkin Denis Vladimirovich Volotova Elena Vladimirovna	RU2622638C1
DERIVATIVES OF QUINAZOLIN-4(3H)-ONE INHIBITING SODIUM-HYDROGEN EXCHANGE	2016	Petrov Vladimir Ivanovich Spasov Aleksandr Alekseevich Ozerov Aleksandr Aleksandrovich Novikov Mikhail Stanislavovich Gurova Nataliya Alekseevna Gurova Valeriya Vitalevna	RU2654062C2
METHOD OF PRODUCING 9-[2-(4-ISOPROPYLPHENOXY)ETHYL])ADENINE	2019	Petrov Vladimir Ivanovich Tyurenkov Ivan Nikolaevich Ozerov Aleksandr Aleksandrovich	RU2714931C1
9-[2-(4-ISOPROPYLPHENOXY)ETHYL]ADENINE POSSESSING ANTIDEPRESSANT AND STRESS-RELIEVING ACTION	2013	Petrov Vladimir Ivanovich Tjurenkov Ivan Nikolaevich Ozerov Aleksandr Aleksandrovich	RU2529817C1
METHOD OF PRODUCING DERIVATIVES OF N2-ALKYL- AND N2,N2-DIALKYLISOCYTOSINE	2017	Novakov Ivan Aleksandrovich Babushkin Aleksandr Sergeevich Brunilina Lejla Lipparitovna Kirillov Ivan Aleksandrovich Mkrtchyan Artur Sergeevich Navrotskij Maksim Borisovich Robinovich Mariya Dmitrievna Shejkin Dmitrij Stanislavovich Yablokov Aleksandr Sergeevich	RU2664121C1

RU 2 489 427 C1

Authors

Petrov Vladimir Ivanovich

Ozerov Aleksandr Aleksandrovich

Luganchenko Andrej Igorevich

Dates

2013-08-10—Published

2012-07-18—Filed