DERIVATIVES OF CHROMENONE AND CHROMANONE AS INTEGRIN INHIBITORS Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of chromenone and chromanone taken among the group including the following compounds: (2S)-3-{2-[3-(1H-imidazol-2-ylamino)propyl]-4-oxo-4H-chromen-6-yl}-2-(2,2-dimethylpropoxycarboxamido)propionic acid ethyl ester; (2S)-3-{2-[3-(1H-imidazol-2-ylamino)propyl]-4-oxo-4H-chromen-6-yl}-2-(2,2-dimethylpropoxycarboxamido)propionic acid; (2S)-3-{2-[3-pyridin-2-ylamino)propyl]-4-oxo-4H-chromen-6-yl}-2-(2,2-dimethylpropoxycarboxamido)propionic acid; (2S)-3-{2-[3-(pyridin-2-ylamino)propyl]-4-oxo-4H-chromen-6-yl}-2-butylsulfonamidopropionic acid; (2S)-3-{2-[3-pyridin-2-ylamino)propyl]-4-oxo-4H-4H-chromen-6-yl}-2-benzylsulfonamidepropionic acid and their physiologically acceptable salts, enantiomers or diastereomers also. These compounds are inhibitors of α_vβ₃-integrins used for control of angiogenic diseases caused by pathological factors, namely: thrombosis, myocardium infarction, heart ischemic disease, artheriosclerosis, tumors, osteoporosis and rheumatic arthritis. Invention relates also to pharmaceutical composition based on these compounds and to method for its preparing.

EFFECT: improved preparing method, valuable medicinal properties of compounds and composition.

5 cl, 2 tbl, 17 ex