BICYCLIC AROMATIC AMINO ACIDS Russian patent published in 2002 - IPC

FIELD: organic chemistry, amino acids. SUBSTANCE: invention describes compounds of the formula (I) where X, Y, Z, R¹,R²,R³,R⁴,R⁵,R⁶,R⁷,R⁸,R¹¹, m and n have values given in the description text and also their physiologically acceptable salts, enantiomers or diastereomers. Proposed compounds and their physiologically acceptable salts can be used as an integrin inhibitors and first of all for prophylaxis and treatment of diseases of cardiovascular system, thrombosis, myocardium infarction, heart ischemic disease, arteriosclerosis, osteoporosis, in pathological processes associated or caused by angiogenesis and for therapy of tumor diseases. Invention gives a method of synthesis of compounds of the formula (I) and their salts. Invention describes also the preparing a pharmaceutical composition inhibiting α-integrin and comprising compound of the formula (I) and/or one of its physiologically acceptable salts. EFFECT: improved method of synthesis of compounds, preparing pharmaceutical composition, valuable medicinal properties. 5 cl, 1 tbl _